Roles of vascular endothelium in atherogenesis.
نویسندگان
چکیده
منابع مشابه
Commentary Vascular Endothelium, Hemodynamic Forces, and Atherogenesis
Intimal lipid accumulation, hyperplasia, and scarring are stigmata of atherosclerotic vascular disease, whose major complications—myocardial and cerebral ischemia and infarction—continue to be major health problems in developed nations. This insidiously progressive disease typically spans decades, but can reach a clinical horizon in a matter of minutes due to critical changes in a given atheros...
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OBJECTIVE Peroxynitrite, a potent oxidant generated by the reaction of NO with superoxide, has been implicated in the promotion of atherosclerosis. We designed this study to determine whether peroxynitrite induces its proatherogenic effects through induction of endoplasmic reticulum (ER) stress. METHODS AND RESULTS Human vascular endothelial cells treated with Sin-1, a peroxynitrite generator...
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Although it has been known for many years that dietary lipids influence the development of atherosclerosis, in the past this has been attributed to their effects on blood cholesterol levels. Recent work, however, has shown that CMRs (chylomicron remnants), the lipoproteins which carry dietary lipids in the blood, potentially have a direct role in initiating atherogenesis by influencing vascular...
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ژورنال
عنوان ژورنال: Ensho
سال: 1995
ISSN: 0389-4290,1884-4006
DOI: 10.2492/jsir1981.15.371